Bonafide’s new hormone-free supplement targets the sleep disruptions that come with menopause

Sleep is one of the most disruptive—and least discussed—symptoms of the menopause transition. Bonafide Health has released Noctera™, to target that exact problem, with a formula that includes SAMe—which, according to Bonafide, makes it the only sleep supplement designed specifically for menopausal women to feature the ingredient.

Bonafide Health has released Noctera™.

How Noctera works

Noctera uses a continuous-release formula, meaning it releases gradually throughout the night rather than all at once, which matters for sleep specifically, where the goal isn’t just falling asleep but staying asleep throughout the night. It’s designed to target both the calming (GABAergic) and excitatory (glutamate) pathways in the brain,without sedation or next-day grogginess

Four key ingredients do the work:

• Magnesium glycinate: Blocks the excitatory signals that cause wakefulness
• GABA: Promotes relaxation and calms the mind for better sleep onset
• L-theanine: Works alongside magnesium to block excitatory signals and rebalance the sleep-wake cycle
• SAMe: Supports sleep regulation and further rebalances disrupted pathways

What the research shows

Noctera was tested in a randomized, double-blind, placebo-controlled trial in perimenopausal and postmenopausal women with moderate-to-severe sleep issues:

• 88% of participants saw sleep disturbances drop to within normal limits within three weeks
• Women gained an average of 40 additional minutes of sleep per night
• 89% found it easier to fall back asleep after waking during the night
• Participants reported improvements in morning grogginess, daytime sleepiness, and overall sleep satisfactionNo significant adverse effects were reported

Hormonal shifts during the menopause transition are a major driver of sleep disturbances. Falling asleep is one challenge. Staying asleep is another. But the real frustration for many women is waking up in the middle of the night.

The issue comes down to brain chemistry. As estrogen declines, it disrupts the balance between GABA (a calming neurotransmitter) and glutamate (an excitatory one).

“Estrogen plays a critical role in how our brain regulates temperature, sleep, and mood,” says Dr. Alyssa Dweck, Bonafide’s chief medical officer. “Declining estrogen levels during the menopause transition affect the balance of both GABA and glutamate. This imbalance has direct effects on sleep.”

For a health stage that still doesn’t get enough dedicated solutions, a supplement built specifically around the sleep science of menopause is a meaningful next step.

Where to buy

Noctera is available now without a prescription at hellobonafide.com. Monthly subscriptions are $33.99/month, and three-month subscriptions are $29.99/month.